Genetic data do not provide evidence that lower sclerostin is associated with increased risk of atherosclerosis: comment on the article by Zheng et al

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  Figure 1. Genetic associations of myocardial infarction (MI) in the SOST region and a cis Mendelian randomization (MR) analysis including one sclerostin‐associated variant from each correlation cluster. A Regional association plot of the ‐log10(P) of MI for the SOST region (±100KB either side of SOST), the red and green dashed lines are the P thresholds 1×10‐6 (regional‐wide significance threshold) 1 and 5×10‐8 (genome‐wide significance threshold), respectively. B Quantile‐quantile plot for the ‐log10(P) of MI from the SOST region, the blue shaded area represents the 95% confidence interval. C Linkage disequilibrium plot of the correlations between the five cis sclerostin‐associated variants (rs66838809, rs1107747, rs4793023, rs80107551, and rs76449013). D Forest plot of the cis MR analysis using the two variants most associated with sclerostin with r 2 < 0.2 (rs66838809 and rs1107747, or a proxy variant when unavailable), Bonferroni corrected P threshold = 0.00515. The associations of rs1107747 and rs4793023 with HDL cholesterol and triglycerides have been adjusted for rs72836567 (a variant associated with expression of CD300LG). 3 Since the per SD sclerostin MR associations have been…