Key result
Sie-Zie-Tang alters arterial pressure wave spectrums and tends to normalize pulse Fourier components.
Why the study?
The effects of Sie-Zie-Tang and its main component Radix Aconiti on pressure wave spectrum and their potential to reduce toxic side effects were investigated.
Do Sie-Zie-Tang and Radix Aconiti alter pressure wave spectrum components in rats and humans?
Do Sie-Zie-Tang and Radix Aconiti alter pressure wave spectrum components in rats and humans?
Sie-Zie-Tang and Radix Aconiti alter pressure wave spectrum components, providing a potential mechanism for how heart meridian-related herbs strengthen heartbeats and normalize energy distribution.
Should not change practice; hypothesis-generating for herbal modulation of arterial waveforms in humans.
Extracts of the traditional Chinese formula Sie-Zie-Tang as well as one of its main components, Radix Aconiti were injected into rats intraperitoneally to observe pressure wave spectrum changes at the caudate artery. We found that Radix Aconiti decreased the C0 (DC term of the pulse), C5 and C6 (the harmonic proportions of the 5th and the 6th harmonic), but increased C2 and C3 (the harmonic proportions of the second and the third harmonic) significantly. For Sie-Zie-Tang, the increases of C2, C3, and C4 were accompanied by the decreasing of C0. The decreases of C5, C6 were small and not significant. The additional ingredients in the formula reduce toxic side effects (arrhythmia or heart failure caused by faster and stronger heart beat) due to Radix Aconiti. For human subjects, low dose Sie-Zie-Tang tends to normalize the Fourier components of the pressure wave. Orally taking the formula elevates the harmonic proportion of the harmonic that is lower than normal, but suppresses the higher one. Our results provides a possible mechanism for heart meridian related herbs. It strengthens heart beats, and normalizes energy distribution to different meridians. The study on Sie-Zie-Tang reveals another formula construction to reduce toxic side effects.
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Wang et al. (1997) studied this question. Sie-Zie-Tang and Radix Aconiti was evaluated on Pressure wave spectrum changes. Sie-Zie-Tang and Radix Aconiti altered pressure wave spectrums in rats, and low-dose Sie-Zie-Tang tended to normalize Fourier components of the pressure wave in human subjects.
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