Key result
Higher longitudinal ambulatory BP variability is linked to cognitive decline in older adults with controlled BP.
Why the study?
There has been no study about the association of longitudinal change in ambulatory blood pressure variability and level with cognitive decline in older adults.
Does longitudinal change in ambulatory blood pressure variability predict cognitive decline in older adults with controlled blood pressure?
Cohort
Does longitudinal change in ambulatory blood pressure variability predict cognitive decline in older adults with controlled blood pressure?
p-value: p=0.007
In older adults with controlled blood pressure, increased longitudinal variability in ambulatory BP, rather than absolute BP level, is significantly associated with cognitive decline.
Observational data warrant no practice change in controlled hypertension; leaves open whether targeting BP variability slows cognitive decline.
Background: There has been no study about the association of longitudinal change in ambulatory blood pressure (BP) variability and level with cognitive decline. Objectives: The purpose of the study was to evaluate whether BP changes via ambulatory BP monitoring predict cognitive decline progression. Methods: Twice-annual ambulatory BP readings were examined during 5 years and their relationship with changes in the Japanese version of the Montreal Cognitive Assessment (MoCA-J) scores. BP variability was assessed using SD, coefficient of variation, and average real variability (ARV). Cognitive decline, defined as a change in the MoCA-J score, was assessed, with the threshold set at the quartile showing the greatest decrease, which we categorized as cognitive dysfunction (-4 points or less). Results: = 0.007), consistent across coefficient of variation and ARV. No association was found between changes in BP level and MoCA-J score decline. Conclusions: In older adults with controlled BP, increased BP variability was linked to cognitive decline, warranting further study as a prevention target.
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Hoshide et al. (2025) conducted a cohort in Cognitive decline. Increased ambulatory blood pressure variability was evaluated on Cognitive decline (change in MoCA-J score of -4 points or less) (p=0.007). Increased longitudinal ambulatory blood pressure variability was significantly associated with cognitive decline in older adults with controlled blood pressure (P=0.007).
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