Key result
Lower cerebral perfusion pressure and organ failure are linked to poor outcomes in pediatric coma.
Why the study?
The diversity of illnesses associated with raised intracranial pressure in children with non-traumatic coma and the development of multiple organ failure require evaluation of monitoring methods and prognostic indicators.
Population
49 infants and children with non-traumatic coma from various causes
Comparison
Monitoring of arterial blood pressure, intracranial pressure, and organ system failure scores
Design
Observational cohort study
Follow-up
During admission
Authors
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Should not yet change management in pediatric non-traumatic coma; leaves open whether CPP targets improve outcomes.
Observational (n=49)
In children with non-traumatic coma, lower minimum cerebral perfusion pressure and the development of multiple organ failure are associated with poor neurological outcomes and high mortality.
Tasker et al. (1988) conducted an observational in non-traumatic coma (n=49). Minimum cerebral perfusion pressure and organ system failure was evaluated on Neurological outcome and mortality. In children with non-traumatic coma, poor neurological outcomes were associated with significantly lower minimum cerebral perfusion pressures, and 17 of 19 patients with organ failure died.
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