Key result
Regorafenib linked to recurrent non-obstructive myocardial injury during atrial fibrillation in a case report.
Why the study?
Multikinase inhibitors with anti-vascular endothelial growth factor effects have been reported to increase the risk of myocardial infarction or ischemia, but the mechanisms and incidence during atrial fibrillation remain unclear.
Does regorafenib cause myocardial injury during atrial fibrillation in a patient with metastatic gastrointestinal stromal tumor?
Case Report (n=1)
Does regorafenib cause myocardial injury during atrial fibrillation in a patient with metastatic gastrointestinal stromal tumor?
Regorafenib, a multikinase inhibitor, may be associated with myocardial injury during atrial fibrillation even in the absence of significant coronary artery stenosis.
May warrant monitoring for myocardial injury on multikinase inhibitors during AF; leaves open causal confirmation in prospective cohorts.
UNLABELLED: Multikinase inhibitors with an anti-vascular endothelial growth factor effect have been reported to increase the risk of myocardial infarction or ischemia. We have presented the case of a 72-year-old male who had a metastatic gastrointestinal stromal tumor for which he received targeted therapy and who was admitted to our hospital for recurrent episodes of myocardial injury during atrial fibrillation. Coronary angiography showed insignificant coronary artery stenosis. We also reviewed the incidence of cardiovascular events in patients receiving regorafenib, and the current understanding of the mechanism of targeted therapy-induced myocardial ischemia/infarction.
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Hsiao et al. (2016) conducted a case report in Metastatic gastrointestinal stromal tumor and atrial fibrillation (n=1). Regorafenib was evaluated on Recurrent episodes of myocardial injury. A 72-year-old male receiving regorafenib for a metastatic gastrointestinal stromal tumor experienced recurrent episodes of myocardial injury during atrial fibrillation despite insignificant coronary stenosis.
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