Minimum distance constraints (minDCs) appear in many geometric optimization problems. They pose major challenges for mixed-integer nonlinear programming (MINLP) due to their reverse-convexity. We develop new algorithms for tightening variable bounds in general MINLPs with minDCs. Because many such problems exhibit substantial symmetry, we further discuss an approach for handling rotation symmetries. In a computational study, we examine the performance of the various methods and determine the scenarios in which each approach demonstrates superiority.
No takes yet. Share an insight, caveat, or question.
Hojny et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: