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Berglund, F. Renal clearance of inulin, polyfructosan‐S and a polyethylene glycol (PEG 1,000) in the rat. Acta physiol. scand. 1965. 64. 238–244. The renal clearances of inulin, polyfructosan‐S and PEG 1,000 were measured in the rat by means of a constant infusion technique. The inulin/PEG 1,000 clearance ratio in 10 rats averaged 0.81, and polyfructosan‐S/PEG 1,000 ratio in 10 rats averaged 0.87. The clearance ratios differed signicantly from unity and were not influenced by phlorizin. The restricted filterabliity of the two polysaccharides in the rat is attributed to the pore size of the glomerular membrane, and a relationship between pore size and animal size is suggested.
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Fredrik Berglund (1965) studied this question.
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