Key result
Treatment with 2 percent glutaraldehyde at pH 7.4 and 25 C reduced the titer of infectious coxsackievirus by 2 log10U in 1 minute or less, even in the presence of high organic matter.
Glutaraldehyde at 2% concentration rapidly inactivates coxsackievirus even in the presence of organic matter.
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A study on the rate of inactivation by glutaraldehyde of coxsackievirus was conducted using different concentrations, temperatures, and pH values. It was found, that 2 percent glutaraldehyde at pH 7.4 and 25 C, as recommended for a sporicide, reduced the titer of infectious virus by 2 log10U in 1 min or less. The reduction was not negatively affected by high concentrations of organic matter (serum and animal spillings) in the reaction mixtures.
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May support rapid glutaraldehyde disinfection against coxsackievirus; leaves open translation to human myocarditis prevention or device protocols.
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Saitanu et al. (1975) studied Enterovirus (coxsackievirus) inactivation. Glutaraldehyde was evaluated on Reduction of infectious virus titer (2 log10U reduction). Treatment with 2 percent glutaraldehyde at pH 7.4 and 25 C reduced the titer of infectious coxsackievirus by 2 log10U in 1 minute or less, even in the presence of high organic matter.
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