Key result
The ACE I/D polymorphism, but not BDKRB2-58T/C, was significantly associated with ACE inhibitor-induced cough, particularly in East Asians and older adults.
Why the study?
Do genetic polymorphisms (ACE I/D or BDKRB2-58T/C) predict the risk of ACE inhibitor-induced cough in patients taking ACE inhibitors?
Meta-Analysis
Do genetic polymorphisms (ACE I/D or BDKRB2-58T/C) predict the risk of ACE inhibitor-induced cough in patients taking ACE inhibitors?
The ACE I/D polymorphism is a significant predictor for ACE inhibitor-induced cough, particularly in East Asian and older populations.
ACE I/D genotyping may help predict cough risk on ACE inhibitors in select populations; confirms association but leaves BDKRB2 role open and requires prospective validation.
AIM: Genetic polymorphisms may influence the incidence of angiotensin-converting enzyme (ACE) inhibitor-induced cough. This study aims to investigate this association. METHODS: Ten electronic databases and PharmGKB were systematically searched. Pooled odds ratio values and their 95% CI were used to assess the association, using the random-effects model. RESULTS: A total of 26 studies were included in the review, 17 of them were included from two separated meta-analysis (ACE I/D or BDKRB2-58T/C). Significant association was found between ACE I/D I carriers (ACE gene insertion) and ACE inhibitor-induced cough, showing racial and age differences. CONCLUSION: This study demonstrated that ACE I/D but not BDKRB2-58T/C polymorphism could be a predictor for the risk of ACE inhibitor-induced cough, especially in east Asians and the aged.
No takes yet. Share an insight, caveat, or question.
Mu et al. (2019) conducted a meta-analysis in ACE inhibitor-induced cough. ACE I/D and BDKRB2-58T/C genetic polymorphisms was evaluated on ACE inhibitor-induced cough. The ACE I/D polymorphism, but not BDKRB2-58T/C, was significantly associated with ACE inhibitor-induced cough, particularly in East Asians and older adults.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: