Key result
Different APTT reagents significantly alter clot waveform analysis kinetics and clotting time.
Why the study?
The effects of activators and phospholipid conditions on clot waveform analysis using APTT reagents have not been adequately investigated.
Cross-Sectional (n=65)
No
The composition of APTT reagents, including activators and phospholipids, affects clot waveform analysis.
Reagent-specific CWA differences warrant interpretive caution; leaves open standardized protocols for clinical hemostasis testing.
Background Clot waveform analysis (CWA) based on activated partial thromboplastin time (APTT) is a useful assay for hemostasis. However, the effects of activators and phospholipid conditions on CWA have not been adequately investigated. Therefore, we characterized CWA using four different APTT reagents.
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Kato et al. (2022) conducted a cross-sectional in Hemophilia A (n=65). Different APTT reagents vs. Comparison among four different APTT reagents was evaluated on Clotting time (CT), maximum velocity (Ad|min1|), maximum acceleration (Ad|min2|), and maximum deceleration (Ad|max2|). Differences in the composition and concentration of four APTT reagents significantly affected clot waveform analysis parameters, including clotting time, maximum velocity, maximum acceleration, and maximum deceleration.
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