Key result
Aging and comorbidities alter the pharmacokinetics and dynamics of anesthetic drugs in elderly patients, necessitating tailored perioperative strategies to reduce postoperative complications.
Population
Elderly patients presenting for anesthesia and surgery
Design
Review
Authors
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Aging alters anesthetic PK/PD and postoperative risks in elderly patients; extends knowledge base but leaves optimal strategies open.
A better understanding of the influence of aging on drug pharmacokinetics and dynamics, along with strategies like perioperative beta-blockade and effective analgesia, may improve outcomes in elderly patients undergoing surgery.
John William Sear (2003) conducted a review in Elderly patients undergoing anesthesia and surgery. Anesthetic drugs was evaluated. Aging and comorbidities alter the pharmacokinetics and dynamics of anesthetic drugs in elderly patients, necessitating tailored perioperative strategies to reduce postoperative complications.
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