Key result
Inhibition of angiotensin-converting enzyme shifts the limits of cerebral blood flow autoregulation toward lower blood pressure values without changing baseline cerebral blood flow.
Why the study?
Does angiotensin-converting enzyme (ACE) inhibition alter the limits of cerebral blood flow autoregulation?
Does angiotensin-converting enzyme (ACE) inhibition alter the limits of cerebral blood flow autoregulation?
ACE inhibition shifts cerebral blood flow autoregulation to lower blood pressure ranges, an effect that is modulated by the sympathetic nervous system.
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ACE inhibition may permit lower blood pressure targets without cerebral hypoperfusion; leaves open sympathetic modulation effects in prospective trials.
Paulson et al. (2008) conducted a review in Cerebral blood flow autoregulation. Angiotensin-converting enzyme (ACE) inhibition was evaluated on Limits of cerebral blood flow autoregulation. Inhibition of angiotensin-converting enzyme shifts the limits of cerebral blood flow autoregulation toward lower blood pressure values without changing baseline cerebral blood flow.
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