Key result
RNase-1 reduces post-MI myocardial edema ~14% and improves survival in mice.
Why the study?
Extracellular RNA released from injured cells increases vascular permeability and contributes to myocardial edema formation after acute myocardial infarction, impairing cardiac function.
Does systemic application of RNase-1 reduce myocardial edema and improve survival in a mouse model of acute myocardial infarction?
Does systemic application of RNase-1 reduce myocardial edema and improve survival in a mouse model of acute myocardial infarction?
Absolute Event Rate: 3.56% vs 4.14%
p-value: p=0.039
In a mouse model of acute myocardial infarction, degrading extracellular RNA with RNase-1 reduces myocardial edema, preserves perfusion, and improves survival.
No takes yet. Share an insight, caveat, or question.
RNase-1 attenuates post-MI edema and mortality in mice; leaves open whether extracellular RNA degradation merits human investigation.
Stieger et al. (2017) studied Myocardial infarction. RNase-1 vs. Saline was evaluated on Myocardial edema formation (wet/dry weight ratio) at 24 hours (p=0.039). Systemic application of RNase-1 significantly reduced myocardial edema formation (wet/dry ratio 3.56 vs 4.14) and improved 8-week survival following myocardial infarction in mice.
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