The theoretical substantiation of the choice of active pharmaceutical ingredients to create a medicine for use in the preparation for childbirth

Topicality. The rational preparation of the birth canal is an important task of modern obstetric practice since tears of the soft tissues of a woman in labor are a fairly common problem. Considering rather small number of drugs presented at the pharmaceutical market of Ukraine in the preparation for childbirth it is relevant and necessary to expand the range of drugs that will help reduction of soft tissue ruptures during childbirth.Aim. To theoretically substantiate the choice of active pharmaceutical ingredients (API) for creating extemporaneous suppositories that help in the preparation of the birth canal and reduction of the rupture risk during childbirth.Materials and methods. Diagnostic and analytical methods were used to review the literature. The main resource for finding information was electronic catalogs and databases of some educational institutions and research institutes.Results and discussion. The expediency of introducing hyaluronic acid and some herbal extracts into an extemporaneous drug has been theoretically substantiated. When searching for scientific information and analyzing it, it has been found that the main function of hyaluronic acid is to regulate permeability of tissues, moisturize them, strengthen and increase protection against trauma. Regarding the use of CO2-extracts of aloe, green tea and calendula the necessity of their inclusion in the composition of a new extemporaneous drug has been determined due to the presence of a moisturizing, antiseptic, anti-inflammatory effect.Conclusions. The expediency of using hyaluronic acid and CO2-extracts of aloe, green tea and calendula as active pharmaceutical ingredients when developing extemporaneous suppositories designed to reduce birth trauma to soft tissues has been proven.