Key result
Gamma-glutamyl transferase (GGT) levels remained within the normal control range in all 28 patients with Duchenne muscular dystrophy, despite creatine kinase levels being 14 to 200 times normal.
Why the study?
Can gamma-glutamyl transferase (GGT) be used as a reliable biomarker to distinguish skeletal muscle from liver damage in patients with Duchenne muscular dystrophy?
Population
28 Duchenne muscular dystrophy subjects with proven dystrophin gene mutations and 20 normal male controls.
Comparison
Measurement of serum gamma-glutamyl transferase… vs Normal male controls (n=20).
Design
Cross-sectional
Follow-up
8 hours
Authors
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GGT remains within normal limits in Duchenne muscular dystrophy despite massive creatine kinase elevations, making it a reliable biomarker for distinguishing liver from skeletal muscle damage.
Case-Control (n=48)
Can gamma-glutamyl transferase (GGT) be used as a reliable biomarker to distinguish skeletal muscle from liver damage in patients with Duchenne muscular dystrophy?
GGT remains within normal limits in Duchenne muscular dystrophy despite massive creatine kinase elevations, making it a reliable biomarker for distinguishing liver from skeletal muscle damage.
Rosales et al. (2008) conducted a case-control in Duchenne muscular dystrophy (n=48). Duchenne muscular dystrophy vs. Normal males was evaluated on Serum GGT and creatine kinase levels. Gamma-glutamyl transferase (GGT) levels remained within the normal control range in all 28 patients with Duchenne muscular dystrophy, despite creatine kinase levels being 14 to 200 times normal.
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