Key result
Middle Eastern Arab ethnicity linked to ~33% higher 12-month acute heart failure mortality vs. Indian subcontinent.
Why the study?
There is a need to compare clinical characteristics and outcomes between Middle East Arab and Indian subcontinent acute heart failure patients in the Gulf region.
Do clinical characteristics and outcomes differ between Middle Eastern Arab and Indian subcontinent patients admitted with acute heart failure in the Middle East?
Observational (n=4,539)
Yes
Do clinical characteristics and outcomes differ between Middle Eastern Arab and Indian subcontinent patients admitted with acute heart failure in the Middle East?
Absolute Event Rate: 22.8% vs 17.1%
Acute heart failure patients in the Middle East present a decade younger than Western cohorts, with significant differences in risk profiles and post-discharge mortality between Middle Eastern Arabs and Indian subcontinent expats.
Mortality differences between Arab and Indian subcontinent acute HF patients warrant ethnicity-informed monitoring; leaves open biologic versus socioeconomic drivers.
OBJECTIVE: To compare Middle East Arabs and Indian subcontinent acute heart failure (AHF) patients. METHODS: AHF patients admitted from February 14, 2012 to November 14, 2012 in 47 hospitals among 7 Middle East countries. RESULTS: The Middle Eastern Arab group (4157) was older (60 vs. 54 years), with high prevalence of coronary artery disease (48% vs. 37%), valvular heart disease (14% vs. 7%), atrial fibrillation (12% vs. 7%), and khat chewing (21% vs. 1%). Indian subcontinent patients (382) were more likely to be smokers (36% vs. 21%), alcohol consumers (11% vs. 2%), diabetic (56% vs. 49%) with high prevalence of AHF with reduced ejection fraction (76% vs. 65%), and with acute coronary syndrome (46% vs. 26%). In-hospital mortality was 6.5% with no difference, but 3-month and 12-month mortalities were significantly high among Middle East Arabs, (13.7% vs. 7.6%) and (22.8% vs. 17.1%), respectively. CONCLUSIONS: AHF patients from this region are a decade younger than Western patients with high prevalence of ischemic heart disease, diabetes mellitus, and AHF with reduced ejection fraction. There is an urgent need to control risk factors among both groups, as well as the need for setting up heart failure clinics for better postdischarge management.
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Panduranga et al. (2015) conducted an observational in Acute heart failure (n=4,539). Middle Eastern Arab ethnicity vs. Indian subcontinent ethnicity was evaluated on 12-month mortality. Middle Eastern Arab acute heart failure patients had significantly higher 12-month mortality compared to Indian subcontinent patients (22.8% vs. 17.1%).
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