Key result
Low pre-transplant adiponectin is linked to higher arterial stiffness and increased post-transplant diabetes risk.
Why the study?
The association between serum adiponectin levels and arterial stiffness related to new onset diabetes after renal transplantation was unclear.
Does low pre-transplant serum adiponectin predict arterial stiffness and new onset diabetes after renal transplantation?
Observational (n=90)
No
Does low pre-transplant serum adiponectin predict arterial stiffness and new onset diabetes after renal transplantation?
Absolute Event Rate: 1520% vs 1412%
p-value: p=0.047
Low pre-transplant serum adiponectin levels are associated with increased arterial stiffness and the development of new-onset diabetes after renal transplantation.
May flag renal transplant candidates for closer metabolic and vascular monitoring; hypothesis-generating and should not yet change practice.
Background: The purpose of this study was to determine whether the level of adiponectin in serum of renal transplant patients is associated with arterial stiffness related to new onset diabetes after transplantation (NODAT). Methods: A total of 90 previously non-diabetic patients who underwent renal transplantation between 1999 and 2009 were enrolled. We evaluated their diabetic risk factors, lipid profiles, brachial-ankle pulse wave velocity (baPWV), ankle-brachial blood pressure index (ABPI) and serum adiponectin level before and after transplantation. Results: Eleven (12.2%) patients were diagnosed with NODAT and 79 (87.8%) without (non-NO-DAT). The mean post-transplant serum adiponectin level in NODAT patients was significantly lower than that in non-NODAT patients (11.9 vs. 16.4 μg/ml, p = 0.01), whereas the mean baPWV level in NODAT patients was significantly higher (1686 vs. 1468 cm/s, p = 0.016). We found a significant inverse correlation between mean pre-transplant serum adiponectin and baPWV level (r = -0.27, p = 0.011). Furthermore, patients with lower pretransplant serum adiponectin levels (<20 μg/ml) developed NODAT significantly more frequently than those with higher levels (p = 0.038) and the mean baPWV level in the former was also significantly higher (1520 vs. 1412 cm/s, p = 0.047). Conclusion: Our results indicate that low pre-transplant serum adiponectin level is associated with arterial stiffness in development of NODAT in patients who undergo renal transplantation.
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Nishimura et al. (2012) conducted an observational in New onset diabetes after transplantation (NODAT) and arterial stiffness (n=90). Low pre-transplant serum adiponectin (<20 μg/ml) vs. Higher pre-transplant serum adiponectin (≥20 μg/ml) was evaluated on Mean brachial-ankle pulse wave velocity (baPWV) in cm/s (p=0.047). Low pre-transplant serum adiponectin levels (<20 μg/ml) were significantly associated with higher arterial stiffness (baPWV 1520 vs. 1412 cm/s) and more frequent development of new onset diabetes after renal transplantation.
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