Key result
Persistent higher-stage AKI post-cardiac surgery is linked to ~13-fold higher CKD or mortality risk.
Why the study?
The association of both duration and stage of acute kidney injury with the development of chronic kidney disease after cardiac surgery was unclear.
Does the severity and duration of acute kidney injury after cardiac surgery predict the development of chronic kidney disease or mortality?
Cohort (n=2,009)
Does the severity and duration of acute kidney injury after cardiac surgery predict the development of chronic kidney disease or mortality?
Hazard Ratio: 13.36 (95% CI 8.22–18.72)
Both the duration (>48 hours) and severity of acute kidney injury after cardiac surgery provide significant prognostic value for predicting the development of chronic kidney disease or mortality.
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AKI persistence and stage may flag higher CKD risk after cardiac surgery; leaves open whether targeted interventions alter progression.
Choe et al. (2021) conducted a cohort in Cardiac or thoracic aortic surgery (n=2,009). Persistent or higher stage acute kidney injury vs. Transient stage 1 acute kidney injury was evaluated on New-onset CKD stage 3 or higher or all-cause mortality (HR 13.36, 95% CI 8.22-18.72). Persistent higher stage acute kidney injury after cardiac surgery was strongly associated with new-onset CKD or mortality compared to transient stage 1 AKI (HR 13.36; 95% CI 8.22-18.72).
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