Key result
Postmortem analysis of brain tissue from adult patients with Tourette's syndrome showed reduced cyclic AMP concentrations in 3 of 4 brains, suggesting an abnormality in a second messenger system.
Observational (n=4)
cAMP reduction in TS postmortem brains is hypothesis-generating; leaves open a role for cyclic AMP dysregulation in Tourette syndrome.
Postmortem frontal, temporal, and occipital regions of the brain from adult patients who had a diagnosis of Tourette's syndrome were analyzed for neurochemical alterations. In 3 of 4 TS-affected brains, the concentration of adenosine 3',5'-monophosphate (cyclic AMP) was reduced in all brain regions evaluated. This diminution in cyclic AMP was not associated with a significant change in the activity of the synthesizing enzyme, adenylate cyclase. No significant differences were identified for the neurotransmitter-synthesizing enzymes choline acetyltransferase and glutamate decarboxylase. Concentrations of dopamine, norepinephrine, and the serotonin metabolite 5-hydroxyindoleacetic acid were not altered. Postsynaptic receptor-binding activity for muscarinic cholinergic ([3H]quinuclidinyl benzilate) and beta receptors ([125I]iodocyanopindolol) showed no generalized impairment. It is suggested that symptoms of Tourette's syndrome might be related to an abnormality within a second messenger system.
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Singer et al. (1990) conducted an observational in Tourette's syndrome (n=4). Tourette's syndrome was evaluated on Neurochemical alterations including cyclic AMP concentration. Postmortem analysis of brain tissue from adult patients with Tourette's syndrome showed reduced cyclic AMP concentrations in 3 of 4 brains, suggesting an abnormality in a second messenger system.
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