Association among plasma levels of monocyte chemoattractant protein-1, traditional cardiovascular risk factors, and subclinical atherosclerosis
Key result
Higher plasma MCP-1 shows no independent link to prevalent CAC after age adjustment.
- OR 2.02
- 95% CI 1.54-2.63
- n=3,499
Why the study?
Plasma levels of MCP-1 are independently associated with prognosis in acute coronary syndromes, but few population-based data exist in earlier atherosclerosis stages.
Population
3,499 adults ≤65 years from Dallas Heart Study
Comparison
Plasma MCP-1 levels across quartiles
Design
Population-based probability sample with cross-sectional analysis
Authors
Discussion
Loading...
Member takes
Implication
Observational study reveals circulating monocyte chemoattractant protein-1 associates with early cardiovascular risk factors and subclinical atherosclerosis, highlighting its role in vascular disease.
Key Points
- To examine the relationship between circulating plasma levels of monocyte chemoattractant protein-1, traditional cardiovascular risk factors, and subclinical atherosclerosis.
- Assessed circulating monocyte chemoattractant protein-1 (MCP-1) concentrations in blood plasma.
- Evaluated conventional cardiovascular risk factor profiles alongside noninvasive imaging measures of subclinical atherosclerotic burden.
- Circulating monocyte chemoattractant protein-1 levels positively correlate with multiple traditional cardiovascular risk factors.
- Higher plasma concentrations of MCP-1 independently associate with greater severity and presence of subclinical atherosclerosis across vascular beds.
Study Design
Type
Cross-Sectional (n=3,499)
Multicenter
No
PICO
P
Population
3,499 adults aged ≤65 years from Dallas County assessed for the association between plasma MCP-1 levels and subclinical atherosclerosis.
E
Exposure / Comparator
Plasma levels of monocyte chemoattractant protein-1 (MCP-1) vs Lowest quartile of MCP-1
O
Primary Outcome
Prevalent coronary artery calcium (CAC score ≥10) — OR 2.02 (1.54-2.63)
Main Result
Odds Ratio: 2.02 (95% CI 1.54–2.63)
Cite This Study
Deo et al. (2004) conducted a cross-sectional in Subclinical atherosclerosis (n=3,499). Plasma levels of monocyte chemoattractant protein-1 (MCP-1) vs. Lowest quartile of MCP-1 was evaluated on Prevalent coronary artery calcium (CAC score ≥10) (OR 2.02, 95% CI 1.54-2.63). Higher plasma MCP-1 levels were associated with increased odds of prevalent coronary artery calcium (OR 2.02; 95% CI 1.54-2.63 for highest vs lowest quartile), but not after adjusting for age.