Key result
Human adult cardiac progenitor cells secrete high levels of active homodimeric PAPP-A.
Why the study?
The role and production of pregnancy-associated plasma protein A (PAPP-A) in human adult cardiac progenitor cells and its impact on IGF signaling were not previously characterized.
Population
Human adult cardiac progenitor cells
Comparison
Homodimeric PAPP-A vs PAPPA/proMBP complex production and secretion
Design
Immunofluorescence and enzyme immunoassays study
Authors
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Supports PAPP-A investigation in CPC therapies; leaves open clinical relevance pending in vivo studies.
D’Elia et al. (2013) studied this question. Pregnancy-associated plasma protein A (PAPP-A) production was evaluated on PAPP-A production and secretion in human adult cardiac progenitor cells. Human adult cardiac progenitor cells produce and secrete high amounts of enzymatically active homodimeric PAPP-A, supporting its importance in the IGFs/IGFBPs/PAPP-A axis in CPC biology.
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