What is the clinical evidence from this study?

Population: Myocardial ischemia and reperfusion (n=25). Intervention: Sarafotoxin 6c (S6c) vs. Saline. Primary outcome: Myocardial infarct size (% of area of slice at risk) (p=< 0.05).

What does this research mean for the field?

Pretreatment with the ETB receptor agonist sarafotoxin 6c significantly reduces myocardial infarct size and preserves ETB receptor mRNA expression following ischemia and reperfusion in rats. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

July 8, 2004Journal of Cardiovascular Pharmacology

Sarafotoxin 6c (S6c) Reduces Infarct Size and Preserves mRNA for the ETB Receptor in the Ischemic/Reperfused Myocardium of Anesthetized Rats

Q: What are the key findings of this study?

Pretreatment with sarafotoxin 6c significantly reduced myocardial infarct size compared to saline control (13% vs 35% of area at risk; P<0.05) in a rat model of ischemia and reperfusion.

Q: What does this research mean for the field?

Pretreatment with the ETB receptor agonist sarafotoxin 6c significantly reduces myocardial infarct size and preserves ETB receptor mRNA expression following ischemia and reperfusion in rats. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

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Key result

Sarafotoxin 6c pretreatment cuts myocardial infarct size by ~63% in ischemia-reperfusion.

P<0.05
n=25

Why the study?

The effects of the ETB receptor agonist sarafotoxin 6c on myocardial infarct size and endothelin receptor mRNA in ischemic/reperfused myocardium were investigated.

Does Sarafotoxin 6c reduce myocardial infarct size in anesthetized rats subjected to ischemia and reperfusion?

Structured PICO

Does Sarafotoxin 6c reduce myocardial infarct size in anesthetized rats subjected to ischemia and reperfusion?

Population

25 anesthetized rats subjected to 30 minutes of left main coronary artery occlusion followed by 120 minutes of reperfusion.

Intervention

Sarafotoxin 6c (S6c) bolus dose (0.24 nmol kg-1 i.v.) administered 5 minutes prior to occlusion

Comparator

Saline administered 5 minutes prior to occlusion

Outcome

Myocardial infarct size assessed by triphenyltetrazolium chloridesurrogate

Main Result

Absolute Event Rate: 13% vs 35%

p-value: p=< 0.05

Sarafotoxin 6c reduces myocardial infarct size and preserves ETB receptor mRNA in a rat model of ischemia/reperfusion.

Discussion

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Implication

Hypothesis-generating for ETB agonism in cardioprotection; leaves open translation to human ischemia-reperfusion injury.

Cite This Study

Crockett et al. (2004) studied Myocardial ischemia and reperfusion (n=25). Sarafotoxin 6c (S6c) vs. Saline was evaluated on Myocardial infarct size (% of area of slice at risk) (p=< 0.05). Pretreatment with sarafotoxin 6c significantly reduced myocardial infarct size compared to saline control (13% vs 35% of area at risk; P<0.05) in a rat model of ischemia and reperfusion.

synapsesocial.com/papers/6ab470537f5fa3cef2c085ab https://doi.org/10.1097/00005344-200408000-00002

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Sarafotoxin 6c (S6c) Reduces Infarct Size and Preserves mRNA for the ETB Receptor in the Ischemic/Reperfused Myocardium of Anesthetized Rats

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Sarafotoxin 6c (S6c) Reduces Infarct Size and Preserves mRNA for the ETB Receptor in the Ischemic/Reperfused Myocardium of Anesthetized Rats

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Also Consider

Also Consider