Key result
Long-term weight change shows ~24% heritability, linking significantly to chromosome 20.
Why the study?
The genetic contribution to weight change and its linkage to specific chromosomal regions is unknown.
Cohort
Effect estimate: LOD score 3.10
Long-term weight change demonstrates significant heritability with genetic linkage identified on chromosomes 1 and 20, highlighting potential genetic underpinnings of metabolic risk.
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No immediate clinical implications for weight management; leaves open validation of linkage peaks on chromosomes 1 and 20.
Fox et al. (2005) conducted a cohort in Weight change. Genetic loci (chromosomes 1 and 20) was evaluated on Linkage to short-term (8-year) and long-term (up to 24-year) weight change (LOD score 3.10). Long-term weight change demonstrated a heritability of 0.24, with significant evidence for genetic linkage on chromosome 20 (peak LOD score 3.10) and suggestive linkage on chromosome 1.
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