Key result
The crystal structure of CLIC4 was determined at 1.8 Angstroms, revealing it forms a redox-regulated chloride ion channel with a conductance of 30 pS in artificial bilayers.
Population
Recombinant, wild-type CLIC4 protein
Comparison
X-ray crystallography and functional assessment… vs CLIC1 structure; reducing agent
Design
Preclinical
Authors
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CLIC4 structure offers no immediate clinical translation; leaves open its role in cardiac redox signaling.
The study provides the crystal structure of CLIC4 and demonstrates its ability to form a redox-regulated chloride ion channel in vitro.
Littler et al. (2005) studied this question. Recombinant CLIC4 protein was evaluated on Crystal structure and ion channel activity. The crystal structure of CLIC4 was determined at 1.8 Angstroms, revealing it forms a redox-regulated chloride ion channel with a conductance of 30 pS in artificial bilayers.
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