Key result
Novel heart valve supporting frame achieves fatigue life exceeding 10^9 cycles in computational modeling.
Why the study?
Fatigue strength of the supporting frame of a novel heart valve prosthesis designed for valve-in-valve reoperation was evaluated to ensure durability.
A novel heart valve bioprosthesis designed for valve-in-valve procedures demonstrated adequate fatigue strength (≥10^9 cycles) in finite element modeling.
Supports further preclinical development; leaves open whether modeled fatigue life predicts clinical durability.
The aim of the study was to evaluate fatigue strength of the supporting frame of the developed heart valve prosthesis designed for "valve-in-valve" reoperation of the incompetent prosthetic valve using finite element method. Materials and Methods.We evaluated fatigue strength of the supporting frames of experimental heart valve prosthesis, developed in the Research Institute for Complex Issues of Cardiovascular Diseases (Kemerovo), intended for redo-implantation.The study was carried out in two successive stages: modeling of supporting frame implantation for each valve dimension and assessment of fatigue strength.The pressure applied to the inner frame side in the region of commissural posts was used as a load.Results.During the implantation phase, a significant increase of mechanical stresses in the corners of the cells with the formation of elastic-plastic hinges was identified.Analysis of fatigue strength of the frame showed a minor level of alternating stress in a loadingunloading cycle: maximal values of 17.2 MPa were observed during hypertensive pressure for 19 mm size.Goodman factor and its distribution on the diagram allowed us to characterize the presence and location of the most critical points of the supporting frames.Maximal values of this parameter ranged from 0.46 to 0.72. Conclusion.The results demonstrated that the tested design of the supporting frame of the experimental heart valve prosthesis provides fatigue life not less than 10 9 cycles.
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Klyshnikov et al. (2017) studied Incompetent prosthetic valve requiring valve-in-valve reoperation. Experimental heart valve prosthesis supporting frame was evaluated on Fatigue strength of the supporting frame. Finite element modeling of the experimental heart valve prosthesis supporting frame demonstrated a fatigue life of not less than 10^9 cycles, with maximal alternating stress of 17.2 MPa.
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