Key result
Plasma NGAL and IL-9 levels measured before, during, and after cardiopulmonary bypass did not significantly predict the incidence of acute kidney injury in patients undergoing coronary artery bypass graft.
Why the study?
The incidence of AKI after CABG with CPB at Dr. Soetomo General Academic Hospital is higher than the global average, necessitating identification of predictive biomarkers such as plasma NGAL and IL-9.
Do plasma NGAL and IL-9 levels predict Acute Kidney Injury in patients undergoing CABG with CPB?
Observational (n=21)
No
Do plasma NGAL and IL-9 levels predict Acute Kidney Injury in patients undergoing CABG with CPB?
Plasma NGAL and IL-9 levels measured before, during, and after cardiopulmonary bypass do not significantly predict the occurrence of acute kidney injury in CABG patients.
Background: Acute Kidney Injury (AKI) incidence of postoperative Coronary Artery Bypass Graft (CABG) with Cardipulmonary Bypass (CPB) at Dr. Soetomo General Academic Hospital reached 69.8%, higher than the global average of 5-20%. Predictors of postoperative AKI are needed; potential biomarkers include plasma Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Interleukin-9 (IL-9). This study aims to analyze the predictive ability of these two biomarkers. Methods: This is a prospective observational study in CABG patients with CPB without previous renal abnormalities at Dr. Soetomo in September-December 2020. Examination of plasma NGAL and IL-9 was carried out before, during, and after the CPB procedure. Results: 21 patients were included in the study, 17 people (81.0%) were male. AKI experienced 14 people (66.7%); 3 people (14.3%) died. Patients without AKI had higher plasma NGAL results at preinduction (17.9±10.3 vs 17.1±15.5), durante (20.5±8.2 vs 16.9±7.8), and early ICU (24.0±8.6 vs 22.9±10.4). Patients with AKI had higher plasma IL-9 results at preinduction (63.3±23.2 vs 55.7±15.8), durante (45.2±11.0 vs 44.2±9.2), and early ICU (49.6±11.3 vs 46.2±15.6). There was no statistically significant relationship between plasma NGAL and IL-9 results. Conclusion: Most CABG patients undergoing CPB have AKI. Patients without AKI had higher NGAL results and lower IL-9 in plasma. Statistically, neither of them can be used as predictive biomarkers of the incidence of AKI so far.
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Adisurya et al. (2021) conducted an observational in Acute Kidney Injury after Coronary Artery Bypass Graft (n=21). Plasma NGAL and IL-9 levels vs. Patients without Acute Kidney Injury was evaluated on Incidence of Acute Kidney Injury (AKI) and its association with plasma NGAL and IL-9 levels. Plasma NGAL and IL-9 levels measured before, during, and after cardiopulmonary bypass did not significantly predict the incidence of acute kidney injury in patients undergoing coronary artery bypass graft.
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