Cuttlebone extract (Sepia officinalis) exerts its anti-inflammatory effects via suppression of the NF-κB signaling pathway

Green synthesis of nanoparticles (NPs) has attracted the researcher's attention, this is because of its rapid, cost-effective, sustainable and eco-friendly nature.The present study reports the successful green synthesis of Zinc oxide nanoparticles (ZnO NPs) using Microtrichia perotitii DC plant leaf extracts as a chelating and capping agent and Zinc Oxide (ZnO) as a precursor.The synthesized nanoparticles were thoroughly characterized using UV-visible spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy and thermogravimetric analysis.X-ray diffraction patterns revealed that ZnO NPs with an average crystallite size of 12.6 nm were synthesized.Scanning electron microscope images show a grain-like nature and with no well-defined morphology.Fourier transform infrared spectrophotometer analysis revealed that the strongest bond at 686 cm -1 corresponds to stretching vibration mode of Zn-O nanoparticles while TGA affirmed the thermal stability of the nanoparticles.The synthesized nanoparticles exhibited antimicrobial activity only against B. subtilis with 25.325 ± 3.51 mm zone of inhibition.