Key result
Unfractionated heparin remains the standard CPB anticoagulant but requires strict monitoring and neutralization.
Why the study?
Despite advances in anticoagulant drugs, unfractionated heparin remains the standard for anticoagulation during cardiopulmonary bypass, but its use is associated with significant complications and variable protocols.
Population
Patients undergoing cardiovascular surgery requiring cardiopulmonary bypass
Comparison
Anticoagulation management strategies including unfractionated heparin, ACT monitoring, protamine neutralization, and aprotinin
Design
State-of-the-art review
Authors
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Alerts to persistent heparin complications in CPB; leaves open safer alternatives for prospective trials.
This review highlights the importance of standardized anticoagulation protocols, including ACT monitoring and precise protamine reversal, to manage the complex hemostatic challenges during cardiopulmonary bypass.
Roque Pifarré (1995) conducted a review in Cardiovascular Surgery / Cardiopulmonary Bypass. Anticoagulation (Heparin) was evaluated. A review of anticoagulation during cardiopulmonary bypass highlights that while unfractionated heparin remains the drug of choice, careful monitoring and neutralization are required to minimize complications.
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