Key result
Standard cytogenetic analysis confirmed a case of primary renal synovial sarcoma by demonstrating the characteristic t(X; 18)(p11.2:q11.2) translocation.
Case Report (n=1)
Cytogenetic analysis can distinguish primary renal synovial sarcoma from sarcomatoid renal cell carcinoma by identifying specific chromosomal translocations.
May aid distinction of rare renal sarcomas from RCC variants; leaves open routine adoption without further validation.
Primary synovial sarcoma rarely originates in the renal parenchyma. When this occurs, origin of this unusual tumor type has been the subject of debate in the literature, with a suggestion that previously reported cases may be more correctly described as renal cell carcinoma with sarcomatoid dedifferentiation. Synovial sarcoma and sarcomatoid renal cell carcinoma may be indistinguishable on pure histologic and immunohistochemical grounds, but these tumors contain distinctly different sets of chromosomal abnormalities. Most previous cases of primary renal synovial sarcoma were confirmed by molecular biology techniques, which detected the SYT-SSX gene fusion transcript typical of this tumor, but no details of the other chromosomal anomalies have been published. We report a case of primary renal synovial sarcoma confirmed by standard cytogenetic analysis, showing the characteristic t(X; 18)(p11.2:q11.2) translocation and other chromosomal aberrations that are typical of synovial sarcoma as opposed to sarcomatoid renal cell carcinoma.
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Shannon et al. (2005) conducted a case report in Primary renal synovial sarcoma (n=1). Standard cytogenetic analysis was evaluated on Detection of chromosomal abnormalities. Standard cytogenetic analysis confirmed a case of primary renal synovial sarcoma by demonstrating the characteristic t(X; 18)(p11.2:q11.2) translocation.
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