Key result
High-dose BCNU and other alkylating agents demonstrate a linear relationship between in-vitro concentration and logarithmic cancer cell kill, though dose escalation is limited by myelosuppression.
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For many chemotherapeutic agents and in particular alkylating agents there is a linear relation between in-vitro concentration and logarithmic cell kill of cancer cell lines [1]. Since myelosuppres...
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Koen van Besien (2006) studied this question. High-dose BCNU and other alkylating agents demonstrate a linear relationship between in-vitro concentration and logarithmic cancer cell kill, though dose escalation is limited by myelosuppression.
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