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Butein is known to be the major component of the bark of Rhus verniciflua Stokes (Anacardiaceae). The aim of this work was to investigate the effects of butein on liver fibrosis induced by carbon tetrachloride (CCl 4 ) in rats, and to explore its antifibrogenic mechanism. Butein (10 mg/kg/day or 25 mg/kg/day) showed a significant reduction of hydroxyproline and malondialdehyde levels in rats. The expression of α1(I) collagen and tissue inhibitor of metalloproteinase-1 (TIMP-1) mRNAs in liver was clearly reduced in a dose-dependent manner in rats given butein compared with control CCl 4 -treated rats. These data suggest the potential of butein to serve as an antifibrogenic agent by inhibition of collagen accumulation and lipid peroxidation, and by down-regulation of the expression of both α1(I) collagen and TIMP-1 mRNA. Abbreviations ALT:alanine aminotransferase AST:aspartate aminotransferase CCl 4 :carbon tetrachloride ECM:extracellular matrix TBARS:thiobarbituric acid reactive substance TIMP-1:tissue inhibitor of metalloproteinase-1
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Lee et al. (2003) studied this question.
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