Key result
Emerging PAD pharmacotherapies target atherosclerosis progression, plaque stability, thrombosis, angiogenesis, and microvascular flow.
Why the study?
Peripheral arterial disease pathophysiology involves complex vascular and microcirculatory changes, motivating development of targeted pharmacotherapies.
This review outlines the pathophysiology of peripheral arterial disease and identifies rational targets for future drug interventions.
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Novel PAD vascular biology insights may guide therapy development; leaves open clinical impact pending prospective validation.
John P. Cooke (1997) conducted a review in Peripheral Arterial Disease. Future pharmacotherapy for peripheral arterial disease will target atherosclerosis progression, plaque rupture, thrombosis, angiogenesis, microvascular derangements, and blood rheology.
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