All articles of this category A new method is described for the synthesis of tert -butoxy-carbonylaminoalkanenitriles 3 by dehydration of the corresponding carboxamides 2 (prepared in two steps from aminoalkanoic acids) in the presence of trifluoroacetic anhydride and triethylamine. N -Boc-ami-noalkanenitriles 3 are easily converted to mono- N -Boc-alkanediamines 4 under mild conditions avoiding the cleavage of the N -protective group. The monoprotected alkanediamines 4 are useful tools in affinity chromatography.
No takes yet. Share an insight, caveat, or question.
Houssin et al. (1988) studied this question.