Key result
Catheter ablation for supraventricular arrhythmias increases hsTnT in all patients, peaking highest in AF.
Why the study?
Levels of cardiac necroenzymes after radiofrequency catheter ablation for different supraventricular arrhythmias and electrophysiological studies without ablation were not well characterized.
Does radiofrequency catheter ablation increase hsTnT and CKMB levels compared to electrophysiological studies in patients with supraventricular arrhythmias?
Observational (n=47)
No
Does radiofrequency catheter ablation increase hsTnT and CKMB levels compared to electrophysiological studies in patients with supraventricular arrhythmias?
High-sensitive troponin T levels significantly increase following radiofrequency catheter ablation in a manner dependent on the arrhythmia substrate and ablation time, which is essential for correctly interpreting post-procedural hsTnT elevations.
hs-TnT rise after ablation may reflect expected injury; leaves open prognostic value in supraventricular arrhythmias.
INTRODUCTION: Levels of cardiac necroenzymes, high-sensitive troponin (hsTnT) and creatine kinase muscle-brain (CKMB) increase as a result of a myocardial damage following catheter ablation. AIM: To analyze the mid-term alteration of hsTnT and CKMB levels following radiofrequency ablation (RFCA) for atrial fibrillation (AF), atrial flutter (AFlu), AV-nodal reentry tachycardia (AVNRT) and electrophysiological studies (EPS) without ablation. METHOD: Patients undergoing RFCA for various indications and EPS were consecutively enrolled in our prospective study. Concentrations of hsTnT and CKMB were measured from serial blood samples directly before and after the procedure, 4 and 20 hours later and at 3 months follow-up. RESULTS: Forty-seven patients (10 EPS, 12 AVNRT, 13 AFlu, 12 AF) with mean age of 55 ± 13 were included. hsTnT levels increased significantly in all groups after the procedures, while CKMB changed only in the AF group. hsTnT exceeded the reference value in all patients with ablation and in 80% of patients with EPS 4 hours post-ablation. Peak average hsTnT levels for EPS, AVNRT, AFlu were 24 ± 11, 260 ± 218 and 541 ± 233 ng/L, respectively. The highest hsTnT level was measured in the AF group (799 ± 433 ng/L). We found a positive correlation between hsTnT levels and ablation time after RFCA. CONCLUSIONS: The hsTnT levels significantly change after EPS and RFCA, in all patients who underwent ablation, and in 80% of those with EPS had hsTnT positivity in the early post-procedural phase. hsTnT levels depended significantly on the type of the subgroups and correlated with the ablation time. Awareness of those observations is essential to correctly interpret elevated hsTnT levels following RFCA. Orv Hetil. 2019; 160(14): 540-548.
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Tahin et al. (2019) conducted an observational in Supraventricular arrhythmias (n=47). Radiofrequency catheter ablation vs. Electrophysiological study without ablation was evaluated on Peak high-sensitive troponin T (hsTnT) level. Radiofrequency catheter ablation for supraventricular arrhythmias significantly increased high-sensitive troponin T levels in all patients, with the highest peak levels in the atrial fibrillation group (799 ± 433 ng/L), and correlated positively with ablation time.