Key result
TNFRSF1B rs1061624 AA genotype is linked to ~51% lower metabolic syndrome risk.
Why the study?
Chronic low-grade inflammation plays an important role in the pathophysiology of metabolic syndrome, but associations of inflammation gene polymorphisms with MetS in the Tatar ethnic group were not established.
Are polymorphic variants of inflammation genes (CRP, TNFA, LTA, TNFRSF1B) associated with an increased risk of metabolic syndrome and altered inflammatory biomarker levels in the Tatar ethnic group?
Case-Control (n=598)
Are polymorphic variants of inflammation genes (CRP, TNFA, LTA, TNFRSF1B) associated with an increased risk of metabolic syndrome and altered inflammatory biomarker levels in the Tatar ethnic group?
Polymorphisms in inflammation genes, particularly TNFRSF1B rs1061624, are significantly associated with metabolic syndrome and systemic inflammation markers in the Tatar population.
Answers are grounded in this paper and cite their sources.
Associated with lower metabolic syndrome risk in Tatars; hypothesis-generating and requires prospective validation before any clinical consideration.
Background and objective — Chronic low-grade inflammation plays an important role in pathophysiology of metabolic syndrome (MetS). The aim of our study was to determine the associations of polymorphic variants of inflammation genes with MetS and serum levels of high-sensitivity C-reactive protein (hsCRP) and tumor necrosis factor-α (TNF-α) in Tatar patients (Bashkortostan). Methods — In our case-control cross-sectional study, 271 MetS patients and 327 healthy Tatars were genotyped for the SNPs in CRP, TNFA, LTA, TNFRSF1B genes. Results — TNFRSF1B (rs1061624) was associated with the MetS [odds ratio (OR)=0.49, рADJ=0.0034] and TNF-α level (p=0.033). TNFA (rs1800629) was associated with TNF-α (p=0.015), albuminuria (p=0.013). CRP (rs2794521) was associated with fasting (p=0.0096) and postprandial (p=0.01) insulin, HOMA-IR (homeostasis model assessment of insulin resistance, p=0.0019), hsCRP (p=0.036), waist-hip ratio (WHR, p=0.007), body mass index (BMI, p=0.039). The participants having the C-C haplotype of CRP rs2794521-rs1130864 were more common among MetS patients (OR=1.99, p=0.032). T-T haplotype in CRP was associated with hsCRP (p=0.0043), low-density lipoprotein cholesterol (p=0.025), HOMA-IR (p=0.00029), glycated hemoglobin (p=0.006), postprandial (p=0.0006) and fasting insulin (p=0.00031), WHR (p=0.00012), BMI (p=0.00024). Conclusions — The data confirms that the variants of inflammation genes CRP, TNFA, TNFRSF1B are associated with levels of TNF-α, hsCRP. Novel association of TNFRSF1B (rs1061624) with MetS had been identified.
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Кочетова et al. (2022) conducted a case-control in Metabolic syndrome (n=598). TNFRSF1B rs1061624 polymorphism vs. Healthy controls was evaluated on Metabolic syndrome (recessive model for TNFRSF1B rs1061624 AA genotype) (OR 0.49, 95% CI 0.30-0.80, p=0.0034). The TNFRSF1B rs1061624 AA genotype was significantly associated with a decreased risk of metabolic syndrome compared to GG and AG genotypes in the Tatar population (OR 0.49).
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