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August 15, 2025Journal of Clinical MedicineOpen Access

Correlations Between Immuno-Inflammatory Biomarkers and Hematologic Indices Stratified by Immunologic SNP Genotypes

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Authors

SASimona-Alina Abu-AwwadClinical Emergency Hospital BucharestAAAhmed Abu-AwwadSpitalul Clinic Judeţean de Urgenţă "Pius Brînzeu" TimişoaraSFSimona Sorina FarcaşVictor Babeș University of Medicine and Pharmacy Timișoara

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Implication

Cross-sectional analysis shows significant genotype relationships affecting inflammatory biomarkers and hemoglobin in adults, suggesting implications for risk assessment.

Key Points

  • IL1RN rs1149222 affects IL-1β and oxidized LDL, highlighting an inflammatory link to erythropoietic suppression.
  • Among 155 adults, TNF-proximal rs2071645 strongly raised TNF-α while red-cell indices remained unchanged.
  • Genotype-specific trends were observed using ANOVA and linear models for blood indices and inflammatory markers.
  • Integrating genotyping with hematologic ratios may enhance early risk stratification and preventive strategies.

Cite This Study

Abu-Awwad et al. (2025) studied this question.

synapsesocial.com/papers/68af5095ad7bf08b1ead8556https://doi.org/10.3390/jcm14165792
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