What question did this study set out to answer?

To investigate the heritability, clinical correlates, and candidate gene associations of systemic inflammatory biomarkers in a community-based cohort.

April 1, 2009Circulation Cardiovascular GeneticsOpen Access

The Relation of Genetic and Environmental Factors to Systemic Inflammatory Biomarker Concentrations

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Authors

RSRenate B. Schnabel KLKathryn L. Lunetta MLMartin G. Larson

Discussion

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Overview

Family-based cohort study reveals genetic and environmental contributions to inflammatory biomarkers, highlighting key candidate gene variants.

Key Points

To investigate the heritability, clinical correlates, and candidate gene associations of systemic inflammatory biomarkers in a community-based cohort.
Analyzed 11 systemic inflammatory biomarkers in 3,710 Framingham Heart Study offspring participants.
Assessed biomarker heritability and bivariate genetic/environmental correlations using Sequential Oligogenic Linkage Analysis routines in 1,012 related individuals.
Evaluated 1,943 tagging single-nucleotide polymorphisms across 233 inflammatory pathway genes using general genetic linear models.
Clinical correlates explained between 2.4% (CD40 ligand) and 28.5% (C-reactive protein) of marker variability, with heritability estimates spanning 10.9% (urinary isoprostanes) to 44.8% (P-selectin).
Identified 45 SNP-biomarker associations meeting a q-value threshold of 0.25, including top cis associations for ICAM1 (rs1799969, P=1.32×10⁻⁸) and MPO (rs28730837, P=1.9×10⁻⁵).
Observed notable trans-acting SNP associations for APCS with monocyte chemoattractant protein-1 (rs1374486, P=1.01×10⁻⁷) and confirmed IL6R with interleukin-6 (rs8192284, P=3.36×10⁻⁵).

Cite This Study

Schnabel et al. (2009) studied this question.

synapsesocial.com/papers/6a0ef3e5a14f152feafa10c3 https://doi.org/10.1161/circgenetics.108.804245

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April 1, 2009Circulation Cardiovascular GeneticsOpen Access

The Relation of Genetic and Environmental Factors to Systemic Inflammatory Biomarker Concentrations

View Full Paper

Ask AI

Bookmark

Authors

RSRenate B. Schnabel KLKathryn L. Lunetta MLMartin G. Larson

Discussion

Member takes

Overview

Family-based cohort study reveals genetic and environmental contributions to inflammatory biomarkers, highlighting key candidate gene variants.

Key Points

To investigate the heritability, clinical correlates, and candidate gene associations of systemic inflammatory biomarkers in a community-based cohort.
Analyzed 11 systemic inflammatory biomarkers in 3,710 Framingham Heart Study offspring participants.
Assessed biomarker heritability and bivariate genetic/environmental correlations using Sequential Oligogenic Linkage Analysis routines in 1,012 related individuals.
Evaluated 1,943 tagging single-nucleotide polymorphisms across 233 inflammatory pathway genes using general genetic linear models.
Clinical correlates explained between 2.4% (CD40 ligand) and 28.5% (C-reactive protein) of marker variability, with heritability estimates spanning 10.9% (urinary isoprostanes) to 44.8% (P-selectin).
Identified 45 SNP-biomarker associations meeting a q-value threshold of 0.25, including top cis associations for ICAM1 (rs1799969, P=1.32×10⁻⁸) and MPO (rs28730837, P=1.9×10⁻⁵).
Observed notable trans-acting SNP associations for APCS with monocyte chemoattractant protein-1 (rs1374486, P=1.01×10⁻⁷) and confirmed IL6R with interleukin-6 (rs8192284, P=3.36×10⁻⁵).

Cite This Study

Schnabel et al. (2009) studied this question.

synapsesocial.com/papers/6a0ef3e5a14f152feafa10c3 https://doi.org/10.1161/circgenetics.108.804245

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