Why the study?
Is educational level associated with inflammatory risk factors for coronary heart disease in the Framingham Offspring Study cohort?
Population
2,729 participants from the US Framingham Offspring Study cohort, mean age 62 +/- 10 years, 53.4% women
Design
Cohort
Key result
Higher educational attainment was significantly inversely associated with C-reactive protein (p=0.0002), sICAM-1 (p=0.01), and MCP-1 (p=0.01) after multivariable adjustment.
Authors
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Supports socioeconomic-inflammatory pathway in CHD risk; hypothesis-generating, should not yet change practice.
Cohort (n=2,729)
Is educational level associated with inflammatory risk factors for coronary heart disease in the Framingham Offspring Study cohort?
p-value: p=0.0002
Lower educational attainment is independently associated with higher levels of inflammatory markers, suggesting a biologic pathway linking socioeconomic position to coronary heart disease risk.
Loucks et al. (2006) conducted a cohort in coronary heart disease (n=2,729). Educational level was evaluated on Inflammatory risk factors for coronary heart disease (C-reactive protein, interleukin-6, soluble intercellular adhesion molecule-1, monocyte chemoattractant protein-1, and P-selectin) (p=0.0002). Higher educational attainment was significantly inversely associated with C-reactive protein (p=0.0002), sICAM-1 (p=0.01), and MCP-1 (p=0.01) after multivariable adjustment.
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