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September 2, 2017BMC GeriatricsOpen Access

Compared with the Low-Low group, participants in the High-High SEP group had significantly lower adjusted CRP (-0.279 ln mg/L; 95% CI: -0.434, -0.125) and IL-6 (-0.129 ln pg/mL; 95% CI -0.236, -0.023).

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Why the study?

Does life-course socioeconomic position predict inflammatory biomarkers (CRP and IL-6) in older age?

Population

1,036 adults aged ≥53 years from the nationally representative Social Environment and Biomarkers of Aging…

Comparison

High-High or Low-High life-course socioeconomic… vs Low-Low life-course socioeconomic position…

Design

Cohort

Authors

YLYu‐Hsuan LinMJMin‐Hua JenKCKuo‐Liong Chien

Discussion

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Member takes

Overview

Suggests lifelong socioeconomic advantage is linked to lower systemic inflammation in older adults; leaves open whether targeted.

Structured PICO

Does life-course socioeconomic position predict inflammatory biomarkers (CRP and IL-6) in older age?

P
Population
1,036 adults aged ≥53 years from the nationally representative Social Environment and Biomarkers of Aging Study (SEBAS) in Taiwan.
I
Intervention
High-High or Low-High life-course socioeconomic position (SEP) trajectories
C
Comparator
Low-Low life-course socioeconomic position (SEP) trajectory
O
Outcome
Levels of C-reactive protein (CRP) and interleukin-6 (IL-6) in older agesurrogate

Consistently high socioeconomic position throughout life is associated with significantly lower levels of inflammatory biomarkers (CRP and IL-6) in older age compared to persistently low socioeconomic position.

Cite This Study

Lin et al. (2017) studied this question.

synapsesocial.com/papers/6a7ca666e98c86b2617cceddhttps://doi.org/10.1186/s12877-017-0598-x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1When do social inequalities in C-reactive protein start? A life course perspective from conception to adulthood in the Cardiovascular Risk in Young Finns Study2007 · 50 citations
  2. 2Life Course Socioeconomic Position and C-Reactive Protein: Mediating Role of Health-Risk Behaviors and Metabolic Alterations. The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)2014 · 30 citations
  3. 3Community Socioeconomic Status is Associated With Circulating Interleukin-6 and C-Reactive Protein2008 · 93 citations
  4. 4Association of Inflammatory Markers With Socioeconomic Status2006 · 152 citations
  5. 5Socioeconomic inequalities in inflammation in childhood and adolescence: an international study across five cohorts2026