Key result
Cumulative socioeconomic disadvantage across the life span was linearly associated with elevated C-reactive protein levels in adulthood, with metabolic alterations mediating 49.5% of this effect in women and 20.2% in men.
Why the study?
Does lower cumulative socioeconomic position across the life course increase C-reactive protein levels in adulthood, and is this mediated by health-risk behaviors and metabolic alterations?
Population
13,371 civil servants from six Brazilian states participating in the ELSA-Brasil baseline cohort. Excluded…
Comparison
Lower cumulative life course socioeconomic… vs Higher cumulative life course socioeconomic…
Design
Cohort
Authors
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May warrant considering life-course disadvantage in inflammation risk assessment; leaves open causal effects and intervention targets.
Cross-Sectional (n=13,371)
Yes
Does lower cumulative socioeconomic position across the life course increase C-reactive protein levels in adulthood, and is this mediated by health-risk behaviors and metabolic alterations?
p-value: p=<0.001
Cumulative socioeconomic disadvantage across the lifespan is associated with higher systemic inflammation in adulthood, an effect that is partially mediated by metabolic alterations and health-risk behaviors, particularly in women.
Camelo et al. (2014) conducted a cross-sectional in Systemic Inflammation (n=13,371). Cumulative socioeconomic position (SEP) disadvantage vs. Higher socioeconomic position was evaluated on C-reactive protein (CRP) levels in adulthood (p=<0.001). Cumulative socioeconomic disadvantage across the life span was linearly associated with elevated C-reactive protein levels in adulthood, with metabolic alterations mediating 49.5% of this effect in women and 20.2% in men.
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