November 12, 2009Obesity
A standardized high-fat meal induced significant increases in circulating WBC (16%), MMP-1 (32%), and MMP-9 (43%) at 4 hours (all P<0.0001), with minimal genetic influence on these changes.
Why the study?
Does a standardized high-fat meal induce heritable changes in inflammatory markers in healthy individuals?
Population
838 related Amish subjects from the Heredity and Phenotype Intervention Heart Study
Comparison
Standardized high-fat meal vs Pre-challenge (baseline) levels
Design
Cohort
Follow-up
4 hours
Key result
A standardized high-fat meal induced significant increases in circulating WBC (16%), MMP-1 (32%), and MMP-9 (43%) at 4 hours (all P<0.0001), with minimal genetic influence on these changes.
Authors
Discussion
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Member takes
Overview
High-fat meals induce acute inflammatory surges largely independent of genetics; hypothesis-generating for dietary cardiovascular risk modulation.
Structured PICO
Does a standardized high-fat meal induce heritable changes in inflammatory markers in healthy individuals?
P
Population
838 healthy related Amish subjects who underwent a standardized high-fat meal challenge to evaluate inflammatory marker changes.
I
Intervention
Standardized high-fat meal
C
Comparator
Pre-challenge (baseline) levels
O
Outcome
Changes in inflammatory markers (CRP, IL-1beta, MMP-1, MMP-9, WBC count) 4 hours after fat challenge and their heritabilitiessurrogate
Main Result
Effect estimate: 16%, 32%, and 43% increases
p-value: p=<0.0001
A high-fat meal induces a significant acute inflammatory response, but unlike basal inflammatory levels, these postprandial changes are largely independent of additive genetic effects.
Cite This Study
Cheng et al. (2009) studied Healthy individuals (n=838). Standardized high-fat meal vs. Baseline (prechallenge) was evaluated on Post-fat load changes in circulating levels of WBC, MMP-1, and MMP-9 (16%, 32%, and 43% increases, p=<0.0001). A standardized high-fat meal induced significant increases in circulating WBC (16%), MMP-1 (32%), and MMP-9 (43%) at 4 hours (all P<0.0001), with minimal genetic influence on these changes.