Key result
A standardised fatty meal significantly increased Mac-1 expression (from 32.2% to 45.6%, p=0.0016) and decreased intracellular MPO (from 83.1% to 64.5%, p<0.0001) at 2 hours.
Why the study?
Does a standardised fatty meal induce an acute inflammatory response in subjects at different degrees of cardiovascular risk?
Population
61 subjects at different degree of cardiovascular risk, without any clinical event
Comparison
Standardised fatty meal administration vs Baseline (before the fatty meal)
Design
Cohort
Follow-up
2 hours
Authors
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Acute postprandial inflammation seen across risk levels; hypothesis-generating and should not yet alter dietary advice.
Observational (n=61)
Does a standardised fatty meal induce an acute inflammatory response in subjects at different degrees of cardiovascular risk?
Absolute Event Rate: 45.6% vs 32.2%
p-value: p=0.0016
A standardised fatty meal induces an acute inflammatory response characterized by leukocyte and platelet activation, which is modulated by baseline cardiovascular risk and demographic factors.
Tamburrelli et al. (2012) conducted an observational in Cardiovascular risk (n=61). Standardised fatty meal vs. Baseline (before meal) was evaluated on Mac-1 expression (p=0.0016). A standardised fatty meal significantly increased Mac-1 expression (from 32.2% to 45.6%, p=0.0016) and decreased intracellular MPO (from 83.1% to 64.5%, p<0.0001) at 2 hours.
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