Key result
Noninvasive arterial compliance and IMT measurements show satisfactory reproducibility over 1 to 5 weeks.
Why the study?
Reproducibility of measurements of arterial compliance has been infrequently reported and little is known about the interrelationships of various indices in vivo.
Comparison
Repeated measurements of arterial compliance and carotid wall thickness on two occasions
Design
Observational study with identical protocol and same investigators
Follow-up
1-5 weeks (mean 2.5 weeks)
Authors
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Satisfactory repeatability supports surrogate endpoints in controlled trials; leaves open reliability for routine clinical use or broader populations.
Observational (n=50)
Non-invasive measurements of central and carotid arterial compliance and intima-media thickness demonstrate satisfactory repeatability in healthy subjects, supporting their use as surrogate markers in clinical trials.
Liang et al. (1998) conducted an observational in Healthy volunteers (n=50). Non-invasive measurements of arterial compliance and wall thickness vs. Repeated measurements (visit 1 vs visit 2) was evaluated on Reproducibility of measurements (Bland-Altman plots of repeatability). Non-invasive measurements of central and carotid arterial compliance and intima-media thickness demonstrated satisfactory repeatability in healthy volunteers over a 1-5 week interval.
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