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We have found in the high speed supernatant fraction from rat liver a macromolecular factor which selectively and reversibly inhibits glucagon responsive adenyl cyclase activity by 90%. This factor does not interfere with epinephrine responsive adenyl cyclase activity nor does it effect the stability of glucagon activation which is not reversed by membrane particle washing. This soluble inhibitor does not appear to be a phosphodiesterase or a peptidase and its synthesis is not dependent on the presence of physiological concentrations of insulin. The soluble inhibitor could function as a component of a feedback loop which regulates glucagon responsive adenyl cyclase by coordinating its activity with epinephrine responsive adenyl cyclase in liver. (Endocrinology89: 1242, 1971)
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Bitensky et al. (1971) studied this question.
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