RP1-13D10.2 Is a Novel Modulator of Statin-Induced Changes in Cholesterol

Katrina Mitchel; Elizabeth Theusch; Celia C. Cubitt; Andrea C. Dosé; Kristen N. Stevens; Devesh Naidoo; Marisa Wong Medina

doi:10.1161/circgenetics.115.001274

April 13, 2016Circulation Cardiovascular GeneticsOpen Access

RP1-13D10.2 Is a Novel Modulator of Statin-Induced Changes in Cholesterol

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Key Points

To determine whether the uncharacterized long noncoding RNA RP1-13D10.2 modulates low-density lipoprotein receptor activity and influences individual variation in cholesterol response to statins.
Assessed simvastatin-induced changes in RP1-13D10.2 and MYLIP expression using lymphoblastoid cell lines from Black and White extreme responders in the Cholesterol and Pharmacogenetics (CAP) trial.
Overexpressed RP1-13D10.2 in Huh7 and HepG2 hepatoma cell lines to evaluate LDLR transcript levels, LDL uptake, apolipoprotein B secretion, and rs6924995 allele-specific effects.
Statin-induced alteration of RP1-13D10.2 expression differed significantly between extreme low-density lipoprotein cholesterol responders, while MYLIP expression showed no difference.
Overexpression of RP1-13D10.2 in hepatoma cells increased LDLR transcript levels, enhanced cellular LDL uptake, and decreased extracellular apolipoprotein B concentrations.
Demonstrated sterol-regulated expression of RP1-13D10.2 alongside rs6924995 allele-dependent trends in modulating LDLR transcript expression.

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Implication

Experimental study reveals that long noncoding RNA RP1-13D10.2 regulates LDL receptor expression in human hepatoma cells, suggesting noncoding RNA drivers of statin response.

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Mitchel et al. (2016) studied this question.

synapsesocial.com/papers/6ab485e27f04a98cfb9ee748 https://doi.org/10.1161/circgenetics.115.001274

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RP1-13D10.2 Is a Novel Modulator of Statin-Induced Changes in Cholesterol

Key Points

No abstract yet

Implication

Discussion

Cite This Study

RP1-13D10.2 Is a Novel Modulator of Statin-Induced Changes in Cholesterol

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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