Impact of risk factors on the development of breast cancer in women from Kyrgyzstan

Introduction and Aim: Breast cancer (BC) is the world's leading oncological disease in terms of prevalence among females and accounts for 25% of all oncological diseases affecting the female population, 25% of women are from the age of 50–60 years. The aim of the study was to determine the risk factors affecting the development of BC in women from Kyrgyzstan (well–known, specific, and protective). Methods: This is a retrospective study that analyzed medical records and outpatient records of 1024 patients with BC treated at the National Center of the Oncology and Hematology of the Ministry of Health of Kyrgyzstan from 2016–2021. Results: Regression analysis showed that out of numerous BC risk factors, only five factors are significant: spontaneous miscarriages (RR = 5.0, p<0.007), preterm birth (RR = 5.0, p<0.007), kidney disease (RR = 5.2, p<0.002), severe anemia (RR = 6.1, p<0.002) and severe postpartum bleeding (RR = 6.9, p<0.002), as indicated by a RR of 0, CI <1, and p<0.001. Conclusion: Based on regression analysis, the presence and influence of specific risk factors for the development of BC in women from Kyrgyzstan were proved: spontaneous miscarriages, premature birth, kidney disease, severe anemia, and severe postpartum bleeding.