Key result
Postmenopausal status is linked to a ~134% higher prevalence of carotid plaque in women.
Why the study?
The potential association of menopause with carotid intima-media thickness and carotid plaque occurrence and stability in Chinese women was unclear.
Does postmenopausal status increase the risk of increased carotid intima-media thickness and unstable carotid plaque in women?
Population
2,131 Chinese women aged above 40 years
Comparison
Postmenopausal status vs premenopausal status
Design
Population-based cross-sectional study
Authors
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Postmenopausal status was associated with higher CIMT, plaque, and instability in Chinese women; leaves open causal inference and prospective validation.
Cross-Sectional (n=2,131)
Does postmenopausal status increase the risk of increased carotid intima-media thickness and unstable carotid plaque in women?
Odds Ratio: 2.335 (95% CI 1.891–2.884)
Absolute Event Rate: 51.9% vs 22.9%
p-value: p=<0.001
Postmenopausal status is independently associated with increased carotid intima-media thickness and a higher prevalence of unstable carotid plaques in Chinese women, highlighting increased subclinical atherosclerotic risk after menopause.
Zhou et al. (2015) conducted a cross-sectional in Carotid Atherosclerosis (n=2,131). Postmenopausal status vs. Premenopausal status was evaluated on Presence of carotid plaque (OR 2.335, 95% CI 1.891-2.884, p=<0.001). Postmenopausal status is significantly associated with a higher prevalence of carotid plaque compared to premenopausal status in Chinese women (adjusted OR 2.335).
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