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The human body is capable of producing antibodies in response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the causative agent of COVID-19. The principle of antigen-antibody reaction has been widely explored to develop enzyme immunoassays for studying seroprevalence. Kelvin Kai-Wang To and colleagues1 found a seropositive rate of 2·73% (53 of 1938 serum samples) in SARS-CoV-2 enzyme immunoassays for individuals who had probably not been exposed to the virus. This finding raises the possibility of antibody cross-reactivity with other human coronaviruses.
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Ma et al. (2020) studied this question.
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