Key result
Type 2 diabetes is linked to impaired microvascular perfusion, predicted primarily by microalbuminuria.
Why the study?
The relationship between microvascular vasomotion, perfusion, and microalbuminuria in Type 2 diabetes was not well characterized.
Does microalbuminuria in Type 2 diabetes indicate impaired microvascular vasomotion and perfusion?
Cross-Sectional
Does microalbuminuria in Type 2 diabetes indicate impaired microvascular vasomotion and perfusion?
p-value: p=<0.001
Microalbuminuria in Type 2 diabetes reflects a generalized disturbance of microvascular function related to endothelium-dependent mechanisms.
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Vasomotion-perfusion links in diabetes need validation; leaves open endothelial stimuli's clinical relevance in microcirculation.
Schmiedel et al. (2007) conducted a cross-sectional in Type 2 diabetes. Type 2 diabetes and microalbuminuria vs. Controls was evaluated on Perfusion and vasomotion responses to local heat, acetylcholine, and sodium nitroprusside (p=<0.001). Type 2 diabetes impaired microvascular perfusion responses to heat (P<0.001), ACh (P=0.003), and sodium nitroprusside (P=0.028), with microalbuminuria being the only consistent predictor.
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