Key result
Human Adenovirus-36 seropositivity in Tehranian youth was associated with a non-significant increase in the odds of elevated triglycerides (OR 3.062; 95% CI 0.344-27.293).
Why the study?
The association between human adenovirus-36 and lipid disorders in children and adolescents was not well established, particularly in Tehranian youth.
Is human adenovirus-36 seropositivity associated with dyslipidemia in Tehranian children and adolescents?
Cross-Sectional (n=54)
No
Is human adenovirus-36 seropositivity associated with dyslipidemia in Tehranian children and adolescents?
In a small cohort of Tehranian youth, human adenovirus-36 seropositivity showed a non-significant trend towards an association with elevated triglycerides and other lipid abnormalities.
Background: The human adenovirus-36 (Adv36) has been associated with obesity and lipid disorders in some countries. The primary dyslipidemia related to obesity is characterized by increased TG, decreased HDL levels and abnormal LDL composition. Childhood obesity is a major public health problem in most developing countries. Objectives: The aim of this study was to investigate the association between Adv36 and lipid disorders in Tehranian youth. Patients and Methods: In a cross-section/observational study, anthropometric, blood pressure and biochemical measurements were examined in 54 youth, aged below 19 years, selected randomly from participants of Tehran Lipid and Glucose Study (TLGS) of Iran. Human Adv36 antibody of serum was determined using ELISA method. Results: Of 54 youth, with a mean age of 14.78 ± 2.62 years, 85.2% were Adv36 seropositive (N = 46) and 14.8% were seronegative (N = 8). Subjects with Adv36 seropositive had higher mean of age, weight, TC, LDL-C, TG and SBP and lower level of HDL-C, waist, FBS and DBP. The unadjusted OR for elevated TG increased in participants who were Adv36 seropositive (OR 3.062, 95% CI: 0.344-27.293). Although the unadjusted OR for other lipid variables, such as elevated TC and LDL-C or decreased HDL-C, tended to increase in participants who were Adv36 seropositive (OR 1.028, 95% CI: 0.996 - 1.060; OR 1.057, 95% CI: 0.107 - 10.481; OR 1.125, 95% CI: 0.238 - 5.325, respectively), the results were not significant. Conclusions: It seems that seropositive Adv36 has a strong association with lipid disorders, especially elevated TG level in Tehranian children and adolescent.
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Zarkesh et al. (2015) conducted a cross-sectional in Dyslipidemia (n=54). Human Adenovirus-36 (Adv36) seropositivity vs. Adv36 seronegativity was evaluated on Elevated TG (OR 3.062, 95% CI 0.344-27.293). Human Adenovirus-36 seropositivity in Tehranian youth was associated with a non-significant increase in the odds of elevated triglycerides (OR 3.062; 95% CI 0.344-27.293).
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